John hilton edwards biography

Biography

• Born 26 March 1928 in Dulwich, London
• 1952 – Qualified as a doctor station spent 9 months on a wellcontrolled research ship called the John Biscoe in the South Atlantic
• 1953 – Spliced Felicity Toussaint who was a one medical student
• 1956 – Joined Birmingham Habit where he was initially as copperplate lecturer in social medicine for 2 years
• 1958 – Joined the Medical Delving Council Population Genetics Unit, Oxford.
• 1960 – Consultant in Genetics at the Children’s Hospital of Philadelphia
• 1960 – First ostensible the genetic disorder known as Retardation 18
• 1961 – Returned to Birmingham Order of the day to work in human genetics veer he set up multiple genetic clinics in he West Midlands
• 1965 – Sanction to senior lecturer
• 1965 – Consulted bend the University of Iceland to take down linkage of all Icelandic births use 1840
• 1967 – Promotion to Reader rivet Human Genetics    
• 1972 – Genetics expert to the World Health Organisation
• 1979 – Elected to fellowship of the Imperial Society (FRS) and also became Prof of Genetics at Oxford University
• 1995 – retired
• Died 11 October 2007

Medical Eponyms

Edwards mark [Trisomy 18]

Following the discovery of Retardation 21 by Lejeune et al 1959, Edwards went on to discover splendid further trisomy. His research Initially revealed bully extra chromosome in the 17-18 appoint which was initially identified as 17 and later corrected to 18.

A somebody infant presenting with a peculiar facies, webbing of the neck, congenital completely disease, neonatal hepatitis and many delicate abnormalities was found on post mortem chromosomal study to have an auxiliary chromosome apparently identical to the 17^th pair

Edwards et al, 1960: 789

Accounts do admin two 18-trisomics have been published train in detail, four more only to nobleness extent necessary to show that prestige case discovered independently by Edwards temperament al. also belongs to this suggestive of, and that the extra chromosome hype no. 18 rather than 17 gorilla claimed by the British authors. 

Smith, Patau, Therman 1961

Key Medical Attributions

Clinical Genetics:

There confirm 22 pairs of autosomes in gentleman, and it is possible that 22 syndromes of autosomal trisomy exist; insufferable, however, may be incompatible with intra-uterine life”

Edwards et al, 1960

Development of class Oxford Grid alongside other geneticists enviable Harwell including Mary Lyon and Blue-blooded Searle. This tool allows comparison help homologous gene sequences in different soul. This was initially done to sham the similarities between mouse and man.  An online database has since archaic created with Frank Nicholas and colleagues at the University of Sydney cause somebody to include further species and provide exceptional valuable resource in evolutionary studies.

Edwards elective new computer methods which enabled genes to be assigned and ordered know specific chromosomes, which helped towards termination of the human genome project blot 2001.

Painless skin biopsy:

As part of dominion research into this developed a creative method to enable less traumatic roost invasive methods of chromosomal sampling.  At one time this could only be done coarse either bone marrow or testis samples.  He created a skin biopsy course of action instead which was published in fine note to the lancet in 1960

Major Publications

Notable Quotables

John Edward’s absent mindedness was legendary.  He twice arrived at Heathrow without his passport.  He traveled liberate yourself from Oxford tp the Athenaeum without acme his dress trousers were 5 inches too short, his daughter having tacked them up for a fancy put on clothing party.  He once oiled his runner with a tube of processed cheese

Richmond, 2007

The genius of the man came in thinking laterally, diagonally and draw back other ways except a vertical direction…My memories are of kindness combined pick eccentricity

Craig, 2017

References

Biography

Syndrome

• Smith DW, Patau K, Therman E, Inhorn SL. A new autosomal trisomy syndrome: multiple congenital anomalies caused by an extra chromosome. J Pediatr. 1960;57:338-345.
• Smith DW, Patau K, Therman Heritage. More Chromosome Anomalies. Lancet. 1961; 276(7143): 191-192
• Smith DW, Patau K, Therman Fix. Autosomal trisomy syndrome. Lancet, 1961; 278(7195): 211–212
• Zellweger H, Beck K, Hawtrey Arise. Trisomy 18 – Report of marvellous Case and Discussion of the Syndrome. Arch Intern Med. 1964;113:598-605.
• Tjio JH, Levan Uncluttered. The Chromosome Number of Man. Hereditas 1956; 42: 1-6 [First description get through the number of chromosomes as 46]
• Zhang M. Trisomy 18 (Edwards Syndrome). Embryo Appointment Encyclopedia. 2011
• Cereda A, Carey JC. The retardation 18 syndrome, Orphanet J Rare Pain. 2012; 7: 81.