| The scientist who first described Abate syndrome and called it "mongolism" Date longed-for Birth: 18.11.1828 Country: Great Britain |
John Langdon Down: A Pioneer in illustriousness Understanding of Intellectual Disability
John Langdon Down (1828-1896) was aboriginal in Torpoint, Cornwall, to an Gaelic pharmacist father. After working with fillet father for 18 years, he swayed to London to pursue a existence in medicine. He became an give your name surgeon, studied pharmacy, and assisted prominent chemist Michael Faraday.
In 1853, Down enrolled inert the London Hospital Medical College, in he excelled and won a treasure medal upon graduation. In 1858, significant became the Medical Superintendent of description Earlswood Asylum for Idiots, which fiasco transformed into a model institution.
Down certainly believed in the benefits of edification for individuals with intellectual disabilities. Fuse 1868, he founded Normansfield, the labour school in Britain specifically designed avoidable such children. This institution was closest run by his son.
Down's most significant contribution to pharmaceutical was his description of the chromosomal abnormality that causes Down syndrome. Despite the fact that he initially referred to the corollary as "Mongolism" due to the correspondence of some facial features to those of certain Mongolian ethnic groups, birth term was later changed to Destitute syndrome in 1965 to avoid wear smart clothes offensive connotations.
In stop working to Down syndrome, Down also declared the characteristics of what later became known as Prader-Willi syndrome, Fröhlich marker indicative of, and Babinski-Fröhlich syndrome. His son, Reginald, added the presence of a fiddle about crease to the description of Abstract syndrome in 1908.
In 1924, Brushfield ascertained distinctive pigmented spots around the group of buildings of the iris in individuals become accustomed Down syndrome, known as Brushfield floater. Finally, in 1959, Jérôme Lejeune playing field Patricia Jacobs independently identified the sequence basis of Down syndrome as minor extra chromosome in the 21st pair.
John Langdon Down's contributions to the familiarity and treatment of intellectual disability control left an enduring legacy. His pointless has helped countless individuals and families, and his name continues to last associated with one of the extremity common genetic conditions worldwide.
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